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Wuhan Desheng Biochemical Technology Co., Ltd
Wuhan Desheng Biochemical Technology Co., Ltd
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Application of uricase 9002-12-4 in in vitro diagnostic kit

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Place of Origin: EZHOU,CHINA

브랜드 이름: DESHENG

인증: ISO9001:2008

지불 및 배송 조건

Minimum Order Quantity: 100mg

Delivery Time: 1~3 DAYS AFTER RECEIVING PAYMENT

Payment Terms: T/T L/C PAYPAL

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사양
강조하다:

Good activity

,

High purity

,

Stability

Appearance:
White amorphous powder
specific activity:
≥1.0U/mg
Stability:
-20℃ for one year
Formula:
>30KD
Optimum PH:
8.5~9.5
Optimum Temperature:
> 60℃
Appearance:
White amorphous powder
specific activity:
≥1.0U/mg
Stability:
-20℃ for one year
Formula:
>30KD
Optimum PH:
8.5~9.5
Optimum Temperature:
> 60℃
설명
Application of uricase 9002-12-4 in in vitro diagnostic kit

As an end product of purine metabolism, abnormal concentration of uric acid is closely related to diseases such as gout, renal dysfunction, and metabolic syndrome. In the field of in vitro diagnostics, uricase has become the core component of uric acid detection kits due to its high specificity, strong catalytic activity, and stability. This article will analyze how uricase empowers modern medical testing from four dimensions: mechanism of action, technological pathway, colorimetric system, and clinical value.  


Product Name

Uricase

CAS NO

9002-12-4

Appearance

White freeze-dried powder or liquid

Purity

>90% (SDS-PAGE detection) 

Molecular Weight

Approximately 35KD

ph stability

Around 8.0

Stability

-Stable at 20 ℃ for two years

Enzyme activity

≥10U/mg

Purpose

Used for in vitro diagnostic kit

Manufacturer

Hubei Xindesheng


Molecular damage mechanism of freeze-thaw cycles


Uricase is an oxidoreductase that specifically catalyzes the breakdown of uric acid into uracil, carbon dioxide, and hydrogen peroxide. Its core advantages lie in:


Application of uricase 9002-12-4 in in vitro diagnostic kit 0

Uricase


1. High specificity: only acts on the C-N bond in uric acid molecules, avoiding cross reactions with other biomolecules and ensuring the accuracy of detection results;  

2. Strong catalytic activity: can quickly decompose uric acid at room temperature, shortening detection time;  


3. Stability: Can maintain activity for a long time under suitable conditions, suitable for the production and storage needs of the reagent kit.  


Technical path: Collaborative innovation of dual enzyme coupling method and uricase method


The current mainstream uric acid detection technology is centered around uricase, which amplifies and converts signals through different enzymatic reactions


1. Uricase peroxidase coupling method: uricase catalyzes the generation of hydrogen peroxide from uric acid, which reacts with 4-aminoantipyrine (4-AAP) and chromogenic agents (such as TOPS) under the action of peroxidase (POD) to form a red quinone imine compound. The absorbance of this product is linearly positively correlated with uric acid concentration, making it suitable for batch detection in fully automated biochemical analyzers.  


2. Urinase method: Urinase directly catalyzes the decomposition of uric acid, and indirectly determines the uric acid content by monitoring changes in pH or carbon dioxide production in the reaction system. This method is easy to operate, cost-effective, and suitable for rapid screening in primary healthcare institutions. The collaborative application of two technological paths covers the full scenario requirements from laboratory precision testing to on-site rapid diagnosis.


Color System: Breakthrough Application of TOPS


In the uricase peroxidase coupling method, the performance of the color reagent directly affects the detection sensitivity and stability. A new colorimetric reagent represented by TOPS (N-ethyl-N - (3-sulfopropyl) -3-methylaniline sodium salt) has greatly improved the sensitivity of uric acid detection due to its high water solubility, strong stability, and anti-interference ability.  


Clinical value: from disease diagnosis to health management


The uricase driven in vitro diagnostic kit has demonstrated multiple values in clinical practice:


1. Disease diagnosis: Serum uric acid level is the core indicator for diagnosing gout and an important reference for renal function assessment and metabolic syndrome warning;  


2. Treatment monitoring: By dynamically monitoring uric acid levels, guiding gout patients to adjust the dosage of uric acid lowering drugs and evaluate treatment effectiveness;  


3. Health management: In physical examination scenarios, uric acid testing can identify high-risk populations and promote lifestyle interventions and disease prevention.  


Application of uricase 9002-12-4 in in vitro diagnostic kit 1

Shipping packaging


Hubei Xindesheng Material Technology Co., Ltd. has established a diagnostic enzyme research and development team, which is currently capable of independently producing dozens of enzyme preparations such as uricase for in vitro diagnostic kits. The products have good quality and stable performance, and are highly welcomed by users. If you have any recent purchasing needs, please click on the official website to learn more details or contact me!

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